Blog

New paper: Human and Non-Human Primate Lineage-Specific Footprints in the Salivary Proteome

A very nice study of the proteins in our saliva as compared to our primate cousins came out @MBE - The study is led by our long time collaborator Stefan Ruhl's group. Our results are in line with the general ideas presented in 70's in King and Wilson's classic paper where the dosage differences in … Continue reading New paper: Human and Non-Human Primate Lineage-Specific Footprints in the Salivary Proteome

New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health

A new review paper by the mighty @marie_saitou on the difficulties and promises in integrating evolutionary framework and investigation of genomic structural variants. We talk a lot about how structural variants of different types likely affect function and have evolutionary impact on human phenotypic variation. But, we keep missing these signatures because: 1. They are … Continue reading New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health

New Paper: A new method to investigate the haplotype context of duplicated genes

We have reported a computational method to detect the haplotypes harboring polymorphic gene duplications in the human genome variation dataset. This study is now published in Genome Biology and Evolution. The maestro (is it maestra?), herself drew an amazing image to accompany the piece (hopefully the next cover of the journal?).  Polymorphic duplications can be … Continue reading New Paper: A new method to investigate the haplotype context of duplicated genes

New paper: Independent amylase gene duplications

Stefan (Ruhl) and I recently published a comprehensive survey of the amylase gene copy number and salivary enzyme activity among mammalian species eLife. Petar (Pajic) was the driving force for the sample collection and analysis. Briefly, we found that 1. Amylase copy number evolves extremely fast leading to independent (I daresay convergent) bursts among mammals … Continue reading New paper: Independent amylase gene duplications

New paper: Hotspots of structural variation

Onta (Yen Lung Lin) led the charge in this careful characterization of regions in the genome where that lead to the recurrent formation of structural variation. The paper "Fine-scale characterization of genomic structural variation in the human genome reveals adaptive and biomedically relevant hotspots" is now published in GBE.  This paper has given us some … Continue reading New paper: Hotspots of structural variation

New Paper: An incomplete sweep of a metabolizing gene

A whole gene deletion sounds awful! You lose one entire gene and hence the protein that this gene is coding.  However, there exist several gene deletions which have been maintained polymorphically among human populations. In our previous work, we found that a cellular detoxification gene, the GSTM1, to remain polymorphically deleted in both humans and … Continue reading New Paper: An incomplete sweep of a metabolizing gene