If you follow our work, you may have remembered that we have published a paper on the curious evolution of genetic variation in the growth hormone receptor. Briefly, we have found that a deletion of the third exon of this gene has evolved as a response to starvation conditions. We followed up on this study… Continue reading New paper(s): Trade-offs may have shaped our genomes
Petar Pajic led this project that we designed with Stefan Ruhl Laboratory on how mucin proteins have evolved. The roles of mucins in different biological processes are becoming more appreciated recently in both evolutionary and biomedical fields. However, their evolution was not known. Our work showed that the gain of exonic repeats on existing precursor… Continue reading New paper: Mucus, slime, and a new way for biological functions to evolve
We are delighted to have the GLAM-Evogen symposium back in person. It will be held on August 13, 2022, at the University at Buffalo. The keynote speaker will be Dr. April Wei from Cornell University. For more information and registration, please see https://gokcumenlab.org/glam-evogen/
Izzy Starr (they/them/their) led this project along with our collaborators Ani Sinha, and Kristina Seiffert to investigate the relationship between recent evolution and immune-mediated trends in human skin. Our major finding is that there are specific genes that are expressed in a human-specific manner in the skin which are also involved in psoriasis. Further, these… Continue reading New paper: Thick-skinned apes
A recent study that is a collaboration between Naoki Masuda, Marie Saitou, and my lab is now online Molecular Biology and Evolution. It is a clever construct by Naoki to collectively analyze the allele frequency distributions of different structural variants across the globe. We identified several interesting candidates, including those that were already on our… Continue reading New paper: Using multiple populations to investigate deviations across geographies – structural variation edition
Our paper on adaptive evolution of a very common, exonic deletion polymorphism is now published in Science Advances. https://www.science.org/doi/full/10.1126/sciadv.abi4476 Our press office did an excellent job as usual - The press release is here: http://www.buffalo.edu/news/releases/2021/09/030.html This study is interesting in our opinion for three main reasons: We are showing that the adaptive pressures acting on… Continue reading New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor
We have now compiled the most comprehensive gene expression atlas for different salivary gland types in humans. Here is the link for the paper now published in Cell Reports. Here is the news release from our press office. The highlights and the graphical abstract of the publication really summarizes the findings so I am not… Continue reading New paper: Salivary gland biology
Michael Frachetti and I have written a review on some of the current discussion points in application of ancient genomics to archaeological questions. The main thesis, I think, is summarized as follows: "We argue that the broad and seemingly daunting ethical, methodological, and theoretical challenges posed by archaeogenomics, in fact, represent the very cutting edge… Continue reading New Review: The Impact of Ancient Genome Studies in Archaeology
Ozgur Taskent led this elegant study on the history of Neanderthal introgressions into the human gene pool. We added to the growing lines of evidence that our ancestors have met multiple Neanderthal populations, interacted with them, and now we carry little pieces of DNA from our ancient cousins. Our paper also highlights the deletion polymorphisms… Continue reading New paper: Different Neanderthal ancestors
Bir zamandır laboratuarımızda yaptığımız araştırmaları Türkçe özetlemek gibi bir fikrim vardı. Bu işe başlamak için kendi websitesimizin en uygun medya olacağına karar verdim. Amacım geniş bir okuyucu kitlesi tarafından anlaşılabilir bir şekilde hızla değişen ve insanlığın biyolojik temelleri üzerine hiç beklenmedik bulgulara ulaşan alanımı Türkiye'de tanıtmak. Yazılarımı (ve podcast, video, vb. medya linklerini) https://gokcumenlab.org/tag/turkce/ adresinden… Continue reading Türkçe yazılar
Buffalo Evolutionary and Anthropological Genomics Laboratory (BEAGL) 