Buffalo Evolutionary and Anthropological Genomics Laboratory (BEAGL)

Investigating the evolutionary history of genetic variations to explain biological diversity and disease in modern and ancient human populations.

WHAT WE DO

We investigate the contributions of genomic structural variations—beyond single nucleotide variations—to human evolution, combining tools from genomics, functional genetics, anthropology, and evolutionary biology to mechanistically link genetic variation to phenotypic diversity.

RESEARCH INTERESTS

Mutation

What different mutational mechanisms shape the size, functional impact, and genomic distribution of different types of genomic structural variation?

Evolutionary Process

What evolutionary processes maintain (ancient) functional, structural variants that we share with Neanderthals?

Function

How do different types of SVs affect biological function at the genetic, transcriptomic, cellular, and organismal levels?

Featured video
Introduction to Gokcumen Lab

Our work has been picked up by several press outlets. See latest.

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June 26, 2023

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Our work has been picked up by several press outlets. See latest.

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June 26, 2023

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Data and Code

Visit our GitHub repo for codes, applications, and datasets. The links to primary datasets can be found in the relevant publications.

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