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Alber talks at the CIGENE series
October 25, 2023 @ 6:00 am - 7:00 am
Alber will give a talk at the CIGENE Autumn series on Wednesday 25th October, 12:00-12:40(CET)/06:00-06:40(EST)
Speaker: Alber Aqil, University of Buffalo, New York, USA
Title: Evolutionary and functional characterization of genomic deletions in humans
Abstract: A systematic characterization of the function and evolution of structural variants remains an imperative exercise. Here, we show that balancing selection is a significant evolutionary force responsible for the maintenance of ancient deletion polymorphisms, and provide a functional characterization of these deletions. However, many deletions are not in strong linkage-disequilibrium (LD) with single nucleotide variants (SNVs), precluding such functional characterization. To solve this problem, we discuss a new methodology that uses a combination of SNVs weakly in LD with a deletion to impute the deletion, thereby allowing investigation into the function of many more deletions.
Zoom link: https://nmbu.zoom.us/j/67064421833