A whole gene deletion sounds awful! You lose one entire gene and hence the protein that this gene is coding. However, there exist several gene deletions which have been maintained polymorphically among human populations. In […]
New Paper: An incomplete sweep of a metabolizing gene Read More »
Our lab has been excited by genomic structural variation because we believe that they underlie a considerable and underappreciated part of the phenotypic variation in primates. It is just that they are challenging to study
New paper: Structural variants are awesome – And they affect detoxification genes Read More »
Following up our earlier insights into “ancient” human deletion polymorphisms that are shared with Neanderthals or Denisovans, we published a paper in BMC Evolutionary Biology, describing a small, but neat example of likely balancing selection acting on
New paper: Evolutionary history of a common psoriasis associated deletion Read More »
We just published a paper in Genome Biology and Evolution – “Atopic Dermatitis Susceptibility Variants In Filaggrin Hitchhike Hornerin Selective Sweep“. It describes the unusual history of the genetic variation affecting the skin structural protein fillagrin.
Our paper (led by Erica – Yay), a close collaboration with the ever-wise Stefan Ruhl, on the complex evolution of the smaller one of the two salivary mucins, MUC7, is now published – It is
New Paper – Recent evolution of the salivary mucin MUC7 Read More »
Congratulations to Eaaswar. His paper, “Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective” was chosen for the Annual Gabriel W. Lasker Award for the best original scientific article published in the journal,
Lasker award for our paper in Human Biology Read More »
Congratulations to Eaaswar. His paper, “Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective” is out as preprint. It is a general review and a example data analysis of existing structural variation
New paper on structural variants and their anthropological relevance Read More »
We have our first paper from the Buffalo laboratory published at Molecular Biology and Evolution (link here, it is Open Access). The paper describes polymorphic human deletions that are shared with Neandertals or Denisovans. Most of these
Thanks to efforts of Sara, Daniel and Brandon – Everything is functioning like clockwork (an analog one that you have to recalibrate once in a while – :)) – So, here is our first gel
Our first PCR Gel – Proud of my very young team Read More »
We have a new paper regarding variation of retrotransposed genes among healthy individuals: In primates and other animals reverse transcription of mRNA followed by genomic integration creates retroduplications. Expressed retroduplications are either ‘retrogenes’ coding for
Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper and here is the link for the curated datasets. The
