New paper: Thick-skinned apes

Izzy Starr (they/them/their) led this project along with our collaborators Ani Sinha, and Kristina Seiffert to investigate the relationship between recent evolution and immune-mediated trends in human skin. Our major finding is that there are specific genes that are expressed in a human-specific manner in the skin which are also involved in psoriasis. Further, these… Continue reading New paper: Thick-skinned apes

New paper: Using multiple populations to investigate deviations across geographies – structural variation edition

A recent study that is a collaboration between Naoki Masuda, Marie Saitou, and my lab is now online Molecular Biology and Evolution. It is a clever construct by Naoki to collectively analyze the allele frequency distributions of different structural variants across the globe. We identified several interesting candidates, including those that were already on our… Continue reading New paper: Using multiple populations to investigate deviations across geographies – structural variation edition

New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor

Our paper on adaptive evolution of a very common, exonic deletion polymorphism is now published in Science Advances. https://www.science.org/doi/full/10.1126/sciadv.abi4476 Our press office did an excellent job as usual - The press release is here: http://www.buffalo.edu/news/releases/2021/09/030.html This study is interesting in our opinion for three main reasons: We are showing that the adaptive pressures acting on… Continue reading New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor

New paper: Salivary gland biology

We have now compiled the most comprehensive gene expression atlas for different salivary gland types in humans. Here is the link for the paper now published in Cell Reports. Here is the news release from our press office. The highlights and the graphical abstract of the publication really summarizes the findings so I am not… Continue reading New paper: Salivary gland biology

New Review: The Impact of Ancient Genome Studies in Archaeology

Michael Frachetti and I have written a review on some of the current discussion points in application of ancient genomics to archaeological questions. The main thesis, I think, is summarized as follows: "We argue that the broad and seemingly daunting ethical, methodological, and theoretical challenges posed by archaeogenomics, in fact, represent the very cutting edge… Continue reading New Review: The Impact of Ancient Genome Studies in Archaeology

New paper: Different Neanderthal ancestors

Ozgur Taskent led this elegant study on the history of Neanderthal introgressions into the human gene pool. We added to the growing lines of evidence that our ancestors have met multiple Neanderthal populations, interacted with them, and now we carry little pieces of DNA from our ancient cousins. Our paper also highlights the deletion polymorphisms… Continue reading New paper: Different Neanderthal ancestors

New review: Archaic hominin introgression into modern human genomes

I wrote a new review paper for the Yearbook of Physical Anthropology. It summarizes some the recent insights from the genomes of archaic humans (e.g., Neanderthals, Denisovans, etc.) within an anthropological framework. Specifically, I tried to answer the following questions: How have genomic data from archaic hominins changed our view of human evolution? Is there any doubt… Continue reading New review: Archaic hominin introgression into modern human genomes

New paper: Human and Non-Human Primate Lineage-Specific Footprints in the Salivary Proteome

A very nice study of the proteins in our saliva as compared to our primate cousins came out @MBE - The study is led by our long time collaborator Stefan Ruhl's group. Our results are in line with the general ideas presented in 70's in King and Wilson's classic paper where the dosage differences in… Continue reading New paper: Human and Non-Human Primate Lineage-Specific Footprints in the Salivary Proteome

New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health

A new review paper by the mighty @marie_saitou on the difficulties and promises in integrating evolutionary framework and investigation of genomic structural variants. We talk a lot about how structural variants of different types likely affect function and have evolutionary impact on human phenotypic variation. But, we keep missing these signatures because: 1. They are… Continue reading New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health

New Paper: A new method to investigate the haplotype context of duplicated genes

We have reported a computational method to detect the haplotypes harboring polymorphic gene duplications in the human genome variation dataset. This study is now published in Genome Biology and Evolution. The maestro (is it maestra?), herself drew an amazing image to accompany the piece (hopefully the next cover of the journal?).  Polymorphic duplications can be… Continue reading New Paper: A new method to investigate the haplotype context of duplicated genes