New paper: Neanderthals in Western Asia

Ozgur, after a pretty painful year of hard work, has now compiled a very nice set of derived Neanderthal haplotypes that were introgressed in Western Asia. It is a very nice extension of the excellent work, showing the local impact of introgression.  Here is the link for our paper in Genome Biology and Evolution - … Continue reading New paper: Neanderthals in Western Asia

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New Paper: VCF2TREE – A phylogenetic tool

Erica (Duo Xu) has spearheaded an effort to compile all the small, different methods that we developed for analyzing population genomics data to construct locus-specific phylogenies into a streamlined pipeline. Yousef Jaber, a bright undergrad from our computer science department, end up making a nice GUI for this pipeline. We hope that it would be … Continue reading New Paper: VCF2TREE – A phylogenetic tool

New paper: Of archaic admixture in Africa, cherries, and serendipity

We have a new paper -two years in the making - where we showed evidence for introgression from an African archaic hominin to the ancestors of modern humans. This is a relatively big and, I have to admit, a serendipitous finding, corroborating the emerging notion that an "interbreeding bonanza" has shaped our ancestors. I do … Continue reading New paper: Of archaic admixture in Africa, cherries, and serendipity

New paper: Of light, duplications and UV protection

We have helped Cemali Bekpen and the Max Planck Evolutionary Biology Group of Dr. Tautz in resolving a very complicated and variable gene duplication. Even though, some of the trends remain fuzzy, it is now clear that gene duplications of SPATA31 diversified in humans and remain variable. What is more, some of their function has to do … Continue reading New paper: Of light, duplications and UV protection

New Paper: Lipids and transcripts within the context of cellular senescence

We now published a paper with Atilla Lab describing the systems level analyses of lipidome and transcriptome as the cells age (i.e., as they stop dividing). Our results highlight the multiple roles of different lipid families are playing in this cellular process. The paper got published in Molecular Biosystems - Here is the link (behind a pay-wall unfortunately). … Continue reading New Paper: Lipids and transcripts within the context of cellular senescence

New Paper – The evolutionary roots of disease susceptibility and complex copy number variation

We just published a paper in Genome Biology and Evolution - "Atopic Dermatitis Susceptibility Variants In Filaggrin Hitchhike Hornerin Selective Sweep". It describes the unusual history of the genetic variation affecting the skin structural protein fillagrin. It turns out that a loss of selective pressure, adaptive restrains on a neighboring gene and a high mutation rate … Continue reading New Paper – The evolutionary roots of disease susceptibility and complex copy number variation

Lasker award for our paper in Human Biology

Congratulations to Eaaswar. His paper, "Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective" was chosen for the Annual Gabriel W. Lasker Award for the best original scientific article published in the journal, Human Biology. From the editors' words: "The award was created to recognize Professor Lasker's more than 40 years of service … Continue reading Lasker award for our paper in Human Biology

New paper: Involves pigs, olfactory receptors and lots of genetic variation

Hoover lab led a study that we contributed that is just published in the Journal Chemical Senses. Allelic variation at 4 loci in the human olfactory receptor gene OR7D4 is associated with perceptual variation in the sex steroid-derived odorants, androstenone, and androstadienone. Androstadienone has been linked with chemosensory identification whereas androstenone makes pork from uncastrated … Continue reading New paper: Involves pigs, olfactory receptors and lots of genetic variation