X’s lab led this study on extensive long-read sequencing of multiple bird genomes and follow-up comparative/functional analysis to find interesting overlap between structural variation hotspots and piRNA hotspots. The evolutionary implications of this overlap has
If you follow our work, you may have remembered that we have published a paper on the curious evolution of genetic variation in the growth hormone receptor. Briefly, we have found that a deletion of
Petar Pajic led this project that we designed with Stefan Ruhl Laboratory on how mucin proteins have evolved. The roles of mucins in different biological processes are becoming more appreciated recently in both evolutionary and
A recent study that is a collaboration between Naoki Masuda, Marie Saitou, and my lab is now online Molecular Biology and Evolution. It is a clever construct by Naoki to collectively analyze the allele frequency
Our paper on adaptive evolution of a very common, exonic deletion polymorphism is now published in Science Advances. https://www.science.org/doi/full/10.1126/sciadv.abi4476 Our press office did an excellent job as usual – The press release is here: http://www.buffalo.edu/news/releases/2021/09/030.html
Ozgur Taskent led this elegant study on the history of Neanderthal introgressions into the human gene pool. We added to the growing lines of evidence that our ancestors have met multiple Neanderthal populations, interacted with
A new review paper by the mighty @marie_saitou on the difficulties and promises in integrating evolutionary framework and investigation of genomic structural variants. We talk a lot about how structural variants of different types likely
We have reported a computational method to detect the haplotypes harboring polymorphic gene duplications in the human genome variation dataset. This study is now published in Genome Biology and Evolution. The maestro (is it maestra?),
Stefan (Ruhl) and I recently published a comprehensive survey of the amylase gene copy number and salivary enzyme activity among mammalian species eLife. Petar (Pajic) was the driving force for the sample collection and analysis.
Onta (Yen Lung Lin) led the charge in this careful characterization of regions in the genome where that lead to the recurrent formation of structural variation. The paper “Fine-scale characterization of genomic structural variation in
A whole gene deletion sounds awful! You lose one entire gene and hence the protein that this gene is coding. However, there exist several gene deletions which have been maintained polymorphically among human populations. In
