We just published a paper in Genome Biology and Evolution - "Atopic Dermatitis Susceptibility Variants In Filaggrin Hitchhike Hornerin Selective Sweep". It describes the unusual history of the genetic variation affecting the skin structural protein fillagrin. It turns out that a loss of selective pressure, adaptive restrains on a neighboring gene and a high mutation rate … Continue reading New Paper – The evolutionary roots of disease susceptibility and complex copy number variation
New Paper – Recent evolution of the salivary mucin MUC7
Our paper (led by Erica - Yay), a close collaboration with the ever-wise Stefan Ruhl, on the complex evolution of the smaller one of the two salivary mucins, MUC7, is now published - It is open access and here is the link. Our great press office, particularly Charlotte Hsu made a nice summary of the … Continue reading New Paper – Recent evolution of the salivary mucin MUC7
Lasker award for our paper in Human Biology
Congratulations to Eaaswar. His paper, "Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective" was chosen for the Annual Gabriel W. Lasker Award for the best original scientific article published in the journal, Human Biology. From the editors' words: "The award was created to recognize Professor Lasker's more than 40 years of service … Continue reading Lasker award for our paper in Human Biology
New paper on structural variants and their anthropological relevance
Congratulations to Eaaswar. His paper, "Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective" is out as preprint. It is a general review and a example data analysis of existing structural variation datasets within an anthropological context. It also made the cover. 🙂 - We hope that it would be helpful to … Continue reading New paper on structural variants and their anthropological relevance
First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces
We have our first paper from the Buffalo laboratory published at Molecular Biology and Evolution (link here, it is Open Access). The paper describes polymorphic human deletions that are shared with Neandertals or Denisovans. Most of these deletions are not introgressed from ancient hominins, but rather have been lingering around since before Human/Neandertal/Denisovan ancestor. As expected majority … Continue reading First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces
Our first PCR Gel – Proud of my very young team
Thanks to efforts of Sara, Daniel and Brandon - Everything is functioning like clockwork (an analog one that you have to recalibrate once in a while - :)) - So, here is our first gel electrophoresis result of a small copy number variable exonic locus.
New Paper in Genome Research: Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division
We have a new paper regarding variation of retrotransposed genes among healthy individuals: In primates and other animals reverse transcription of mRNA followed by genomic integration creates retroduplications. Expressed retroduplications are either 'retrogenes' coding for functioning proteins or expressed 'processed pseudogenes', which can function as noncoding RNAs. To date, little is known about the variation … Continue reading New Paper in Genome Research: Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division
