Omer talks at PacBio event
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Copy Number Variation
New paper: Odd interactions between short RNAs and structural variation
X’s lab led this study on extensive long-read sequencing of multiple bird genomes and follow-up comparative/functional analysis to find interesting overlap between structural variation hotspots and piRNA hotspots. The evolutionary implications of this overlap has
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New paper(s): Trade-offs may have shaped our genomes
If you follow our work, you may have remembered that we have published a paper on the curious evolution of genetic variation in the growth hormone receptor. Briefly, we have found that a deletion of
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New paper: Mucus, slime, and a new way for biological functions to evolve
Petar Pajic led this project that we designed with Stefan Ruhl Laboratory on how mucin proteins have evolved. The roles of mucins in different biological processes are becoming more appreciated recently in both evolutionary and
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New paper: Using multiple populations to investigate deviations across geographies – structural variation edition
A recent study that is a collaboration between Naoki Masuda, Marie Saitou, and my lab is now online Molecular Biology and Evolution. It is a clever construct by Naoki to collectively analyze the allele frequency
New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor
Our paper on adaptive evolution of a very common, exonic deletion polymorphism is now published in Science Advances. https://www.science.org/doi/full/10.1126/sciadv.abi4476 Our press office did an excellent job as usual – The press release is here: http://www.buffalo.edu/news/releases/2021/09/030.html
New paper: Different Neanderthal ancestors
Ozgur Taskent led this elegant study on the history of Neanderthal introgressions into the human gene pool. We added to the growing lines of evidence that our ancestors have met multiple Neanderthal populations, interacted with
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New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health
A new review paper by the mighty @marie_saitou on the difficulties and promises in integrating evolutionary framework and investigation of genomic structural variants. We talk a lot about how structural variants of different types likely
New Paper: A new method to investigate the haplotype context of duplicated genes
We have reported a computational method to detect the haplotypes harboring polymorphic gene duplications in the human genome variation dataset. This study is now published in Genome Biology and Evolution. The maestro (is it maestra?),
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New paper: Independent amylase gene duplications
Stefan (Ruhl) and I recently published a comprehensive survey of the amylase gene copy number and salivary enzyme activity among mammalian species eLife. Petar (Pajic) was the driving force for the sample collection and analysis.
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New paper: Hotspots of structural variation
Onta (Yen Lung Lin) led the charge in this careful characterization of regions in the genome where that lead to the recurrent formation of structural variation. The paper “Fine-scale characterization of genomic structural variation in
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