Omer talks at PacBio event
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Evolution
New paper: Odd interactions between short RNAs and structural variation
X’s lab led this study on extensive long-read sequencing of multiple bird genomes and follow-up comparative/functional analysis to find interesting overlap between structural variation hotspots and piRNA hotspots. The evolutionary implications of this overlap has
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New paper(s): Trade-offs may have shaped our genomes
If you follow our work, you may have remembered that we have published a paper on the curious evolution of genetic variation in the growth hormone receptor. Briefly, we have found that a deletion of
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New paper: Mucus, slime, and a new way for biological functions to evolve
Petar Pajic led this project that we designed with Stefan Ruhl Laboratory on how mucin proteins have evolved. The roles of mucins in different biological processes are becoming more appreciated recently in both evolutionary and
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New paper: Thick-skinned apes
Izzy Starr (they/them/their) led this project along with our collaborators Ani Sinha, and Kristina Seiffert to investigate the relationship between recent evolution and immune-mediated trends in human skin. Our major finding is that there are
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New paper: Using multiple populations to investigate deviations across geographies – structural variation edition
A recent study that is a collaboration between Naoki Masuda, Marie Saitou, and my lab is now online Molecular Biology and Evolution. It is a clever construct by Naoki to collectively analyze the allele frequency
New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor
Our paper on adaptive evolution of a very common, exonic deletion polymorphism is now published in Science Advances. https://www.science.org/doi/full/10.1126/sciadv.abi4476 Our press office did an excellent job as usual – The press release is here: http://www.buffalo.edu/news/releases/2021/09/030.html
New paper: Independent amylase gene duplications
Stefan (Ruhl) and I recently published a comprehensive survey of the amylase gene copy number and salivary enzyme activity among mammalian species eLife. Petar (Pajic) was the driving force for the sample collection and analysis.
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New Paper: An incomplete sweep of a metabolizing gene
A whole gene deletion sounds awful! You lose one entire gene and hence the protein that this gene is coding. However, there exist several gene deletions which have been maintained polymorphically among human populations. In
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New paper: Evolutionary biology of cellular aging (We got the cover)
An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence Press release by Charlotte Hsu Academic minute podcast by our collaborator Ekin Atilla The evolution of cellular senescence is a remarkable question. It
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New paper: Structural variants are awesome – And they affect detoxification genes
Our lab has been excited by genomic structural variation because we believe that they underlie a considerable and underappreciated part of the phenotypic variation in primates. It is just that they are challenging to study
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