Lasker award for our paper in Human Biology

Congratulations to Eaaswar. His paper, "Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective" was chosen for the Annual Gabriel W. Lasker Award for the best original scientific article published in the journal, Human Biology. From the editors' words: "The award was created to recognize Professor Lasker's more than 40 years of service … Continue reading Lasker award for our paper in Human Biology

New paper: Involves pigs, olfactory receptors and lots of genetic variation

Hoover lab led a study that we contributed that is just published in the Journal Chemical Senses. Allelic variation at 4 loci in the human olfactory receptor gene OR7D4 is associated with perceptual variation in the sex steroid-derived odorants, androstenone, and androstadienone. Androstadienone has been linked with chemosensory identification whereas androstenone makes pork from uncastrated … Continue reading New paper: Involves pigs, olfactory receptors and lots of genetic variation

New paper on structural variants and their anthropological relevance

Congratulations to Eaaswar. His paper, "Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective" is out as preprint. It is a general review and a example data analysis of existing structural variation datasets within an anthropological context. It also made the cover. 🙂 - We hope that it would be helpful to … Continue reading New paper on structural variants and their anthropological relevance

First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces

We have our first paper from the Buffalo laboratory published at Molecular Biology and Evolution (link here, it is Open Access). The paper describes polymorphic human deletions that are shared with Neandertals or Denisovans. Most of these deletions are not introgressed from ancient hominins, but rather have been lingering around since before Human/Neandertal/Denisovan ancestor. As expected majority … Continue reading First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces

The lab is now affiliated with Program in Evolution, Ecology and Behavior

We are now affliated iwth the Program in Evolution, Ecology and Behavior (EEB) in University at Buffalo. This may be a good opportunity for graduate students and visiting scientists interested in evolutionary/anthropological genomics to interact with our group. So, we are looking forward to working with the EEB folk in the coming years. Also, Omer will … Continue reading The lab is now affiliated with Program in Evolution, Ecology and Behavior

New Paper in Genome Research: Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division

We have a new paper regarding variation of retrotransposed genes among healthy individuals: In primates and other animals reverse transcription of mRNA followed by genomic integration creates retroduplications. Expressed retroduplications are either 'retrogenes' coding for functioning proteins or expressed 'processed pseudogenes', which can function as noncoding RNAs. To date, little is known about the variation … Continue reading New Paper in Genome Research: Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division

New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper and here is the link for the curated datasets. The study, I think, is a major step forward to understand evolution of primate genomes. Now that several papers from Eichler … Continue reading New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences