New paper: Structural variants are awesome – And they affect detoxification genes

Our lab has been excited by genomic structural variation because we believe that they underlie a considerable and underappreciated part of the phenotypic variation in primates. It is just that they are challenging to study and come up with straightforward evolutionary stories. Most of the time, what we find is much more complicated than we … Continue reading New paper: Structural variants are awesome – And they affect detoxification genes

New paper: Of light, duplications and UV protection

We have helped Cemali Bekpen and the Max Planck Evolutionary Biology Group of Dr. Tautz in resolving a very complicated and variable gene duplication. Even though, some of the trends remain fuzzy, it is now clear that gene duplications of SPATA31 diversified in humans and remain variable. What is more, some of their function has to do … Continue reading New paper: Of light, duplications and UV protection

New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper and here is the link for the curated datasets. The study, I think, is a major step forward to understand evolution of primate genomes. Now that several papers from Eichler … Continue reading New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G

This paper describing a nice evolutionary story about interaction between HIV and the host immune system, is mostly the effort of our collaborators in Mount Sinai. You can find the abstract below and here is the link to the article.  APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 and other lentiviruses. Most of these … Continue reading New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G