We have helped Cemali Bekpen and the Max Planck Evolutionary Biology Group of Dr. Tautz in resolving a very complicated and variable gene duplication. Even though, some of the trends remain fuzzy, it is now clear that gene duplications of SPATA31 diversified in humans and remain variable. What is more, some of their function has to do … Continue reading New paper: Of light, duplications and UV protection
Our paper (led by Erica - Yay), a close collaboration with the ever-wise Stefan Ruhl, on the complex evolution of the smaller one of the two salivary mucins, MUC7, is now published - It is open access and here is the link. Our great press office, particularly Charlotte Hsu made a nice summary of the … Continue reading New Paper – Recent evolution of the salivary mucin MUC7
Jelena Tica from Jan Korbel's group led a rigorous method development effort. You can find the full, open access article here
Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper and here is the link for the curated datasets. The study, I think, is a major step forward to understand evolution of primate genomes. Now that several papers from Eichler … Continue reading New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences
This paper describing a nice evolutionary story about interaction between HIV and the host immune system, is mostly the effort of our collaborators in Mount Sinai. You can find the abstract below and here is the link to the article. APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 and other lentiviruses. Most of these … Continue reading New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G
I am giving a talk tomorrow at AAPAs that touches on the impact of genomic structural variation on the phenotypic diversity within and between primate species. For more details: Link
Bilim kazanı için İlker ve Aysu ile uzunca bir muhabbet ettik. Tatlı dillerinden ayrılıp da eve dönmem gece yarısı 1'i buldu. Ama galiba ayırdığımız 5 saate değdi. İnsanı insan yapan nedir diye sorduk - Dinlemek için basın buraya. Bu arada iyice yaşlandığımı tasdikleyecek ama, FatBoy Slim'in şu klibini hatırlamadım değil... 🙂 https://www.youtube.com/watch?v=ub747pprmJ8
I am the co-first author of a recent paper with Rebecca (Iskow), discussing the impact of copy number differences between primate species to expression regulation. I do think that copy number differences of regulatory genes (e.g., transcription factors) and other regulatory regions (non-coding RNAs, enhancer, etc.) may be key to understand phenotypic variation among primates. … Continue reading Paper in PNAS – Regulatory element copy number differences shape primate expression profiles
We have a new review paper in Trends in Genetics regarding the role of Copy Number Variants (CNVs) in human adaptation. I think, it lays out some of the emerging promises (and hardships) of the field and throws in one or two very cool ideas on the evolutionary mechanisms through which CNVs can affect phenotypic variation in … Continue reading Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation
Our team's effort to rule out a genetic disorder helped get Siri the Chimp get back to health. Pretty cool that this little guy really beat the odds and survived. BWH press release, Oklahoman.
