New paper: Of light, duplications and UV protection

We have helped Cemali Bekpen and the Max Planck Evolutionary Biology Group of Dr. Tautz in resolving a very complicated and variable gene duplication. Even though, some of the trends remain fuzzy, it is now clear that gene duplications of SPATA31 diversified in humans and remain variable. What is more, some of their function has to do … Continue reading New paper: Of light, duplications and UV protection

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New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper and here is the link for the curated datasets. The study, I think, is a major step forward to understand evolution of primate genomes. Now that several papers from Eichler … Continue reading New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G

This paper describing a nice evolutionary story about interaction between HIV and the host immune system, is mostly the effort of our collaborators in Mount Sinai. You can find the abstract below and here is the link to the article.  APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 and other lentiviruses. Most of these … Continue reading New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G

Bilim kazanında günün kepçesi oldum

Bilim kazanı için İlker ve Aysu ile uzunca bir muhabbet ettik. Tatlı dillerinden ayrılıp da eve dönmem gece yarısı 1'i buldu. Ama galiba ayırdığımız 5 saate değdi. İnsanı insan yapan nedir diye sorduk - Dinlemek için basın buraya. Bu arada iyice yaşlandığımı tasdikleyecek ama, FatBoy Slim'in şu klibini hatırlamadım değil... 🙂 https://www.youtube.com/watch?v=ub747pprmJ8  

Paper in PNAS – Regulatory element copy number differences shape primate expression profiles

I am the co-first author of a recent paper with Rebecca (Iskow), discussing the impact of copy number differences between primate species to expression regulation. I do think that copy number differences of regulatory genes (e.g., transcription factors) and other regulatory regions (non-coding RNAs, enhancer, etc.) may be key to understand phenotypic variation among primates. … Continue reading Paper in PNAS – Regulatory element copy number differences shape primate expression profiles

Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation

We have a new review paper in Trends in Genetics regarding the role of Copy Number Variants (CNVs) in human adaptation. I think, it lays out some of the emerging promises (and hardships) of the field and throws in one or two very cool ideas on the evolutionary mechanisms through which CNVs can affect phenotypic variation in … Continue reading Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation