Paper in PNAS – Regulatory element copy number differences shape primate expression profiles

I am the co-first author of a recent paper with Rebecca (Iskow), discussing the impact of copy number differences between primate species to expression regulation. I do think that copy number differences of regulatory genes (e.g., transcription factors) and other regulatory regions (non-coding RNAs, enhancer, etc.) may be key to understand phenotypic variation among primates.… Continue reading Paper in PNAS – Regulatory element copy number differences shape primate expression profiles

Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation

We have a new review paper in Trends in Genetics regarding the role of Copy Number Variants (CNVs) in human adaptation. I think, it lays out some of the emerging promises (and hardships) of the field and throws in one or two very cool ideas on the evolutionary mechanisms through which CNVs can affect phenotypic variation in… Continue reading Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation

Refinement of primate CNV hotspots identifies candidate genomic regions evolving under positive selection

A study that was looking into genomes of different primate species to understand the evolutionary mechanisms underlying "plastic" regions of the primate genomes was published in Genome Biology.  It is one of the "Editor's Picks" and a provisional pdf can be acquired here.

Anthropological genomics in the era of affordable and highthroughput technologies

I was invited to give a talk at American Association of Anthropological Genetics (AAAG).  The organizers of the symposium were Graciela Cabana and Lorena Havill.  I think, they did a great job of putting together a diverse group of researchers to discuss "Anthropological Genetics in the Genomic Era". If you are interested in my talk,… Continue reading Anthropological genomics in the era of affordable and highthroughput technologies

Yerel bariyerler, genetik karışma ve kıtalararası izolasyon

İTÜ Moleküler Biyoloji ve Genetik Kulübü'nün düzenlediği, İTÜ III. Ulusal Moleküler Biyoloji ve Genetik Öğrenci Kongresi'nde uzaktan bir konferans verme fırsatı buldum.  Gerçekten hem artık bu tip uzaktan konferansların olanaklı olduğunu göstermesi açısından çok hoştu, hem de çok zaman geçirdiğim Boğaziçi Bilim Kulübü'ndeki zamanlarımı hatırlattı. ITU Talk - 2009 View more presentations from gokcumen. Konuşmam… Continue reading Yerel bariyerler, genetik karışma ve kıtalararası izolasyon

Copy Number Variants (CNVs) in primate species

We have a new paper out ahead of print in an Elsevier Journal called Methods. Here is the PubMed link. A substantial amount of genomic variation is now known to exist in humans and other primate species. Single nucleotide polymorphisms (SNPs) are thought to represent the vast majority of genomic differences among individuals in a… Continue reading Copy Number Variants (CNVs) in primate species

Zaman Makinesi – Radikal

Radikal İki'de bir yazım yayınlandı.  Bilginize... Bir zaman makineniz olsaydı ve bundan aşağı yukarı yarım milyon yıl öncesine, Denizli'nin Kocabaş köyünün yakınlarındaki travertenlerin civarına gitseydiniz, biraz da şansınız varsa, uzaktan bakıldığında modern bir insanı andıran iki ayağı üzerinde dimdik duran bir figürü seçebilirdiniz...  Devamı.