New paper: Involves pigs, olfactory receptors and lots of genetic variation

Hoover lab led a study that we contributed that is just published in the Journal Chemical Senses. Allelic variation at 4 loci in the human olfactory receptor gene OR7D4 is associated with perceptual variation in the sex steroid-derived odorants, androstenone, and androstadienone. Androstadienone has been linked with chemosensory identification whereas androstenone makes pork from uncastrated … Continue reading New paper: Involves pigs, olfactory receptors and lots of genetic variation

New paper on structural variants and their anthropological relevance

Congratulations to Eaaswar. His paper, "Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective" is out as preprint. It is a general review and a example┬ádata analysis of existing structural variation datasets within an anthropological context. It also made the cover. ­čÖé - We hope that it would be helpful to … Continue reading New paper on structural variants and their anthropological relevance

First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces

We have our first paper from the Buffalo laboratory published at Molecular Biology and Evolution (link here, it is Open Access). The paper describes┬ápolymorphic human deletions that are shared with Neandertals or Denisovans.┬áMost of these deletions are not introgressed from ancient hominins, but rather have been lingering around since before Human/Neandertal/Denisovan ancestor. As expected majority … Continue reading First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces

Our group is now affiliated with Institute for European and Mediterranean Archaeology

We are now officially affiliated with Institute for European and Mediterranean Archaeology, which involve multidisciplinary research and many outstanding colleagues. This is a pretty nice framework for students that want to undertake anthropological fieldwork and archaeogenetics research. Also, very interesting and high-profile international seminar series is a plus.

New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper┬áand here is the link for the curated datasets. The study, I think, is a major step forward to understand evolution of primate genomes. Now that several papers from Eichler … Continue reading New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

New paper in PLoS Genetics – Balancing Selection shaping the distribution of a common deletion variant

Finally, our manuscript entitled "Balancing selection┬áon a Regulatory Region Exhibiting Ancient Variation That Predates HumanÔÇôNeandertal Divergence" was published in PLoS Genetics. You can find it here... It is Open Access. Also, link to the post regarding the manuscript in Dienekes' Anthropology Blog. Note the several interesting points that commentators were raising. Another recent blog post … Continue reading New paper in PLoS Genetics – Balancing Selection shaping the distribution of a common deletion variant