New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor

Our paper on adaptive evolution of a very common, exonic deletion polymorphism is now published in Science Advances. https://www.science.org/doi/full/10.1126/sciadv.abi4476 Our press office did an excellent job as usual - The press release is here: http://www.buffalo.edu/news/releases/2021/09/030.html This study is interesting in our opinion for three main reasons: We are showing that the adaptive pressures acting on … Continue reading New paper: Sex- and environment dependent adaptive evolution of a common deletion in human growth hormone receptor

New Review: The Impact of Ancient Genome Studies in Archaeology

Michael Frachetti and I have written a review on some of the current discussion points in application of ancient genomics to archaeological questions. The main thesis, I think, is summarized as follows: "We argue that the broad and seemingly daunting ethical, methodological, and theoretical challenges posed by archaeogenomics, in fact, represent the very cutting edge … Continue reading New Review: The Impact of Ancient Genome Studies in Archaeology

New paper: Different Neanderthal ancestors

Ozgur Taskent led this elegant study on the history of Neanderthal introgressions into the human gene pool. We added to the growing lines of evidence that our ancestors have met multiple Neanderthal populations, interacted with them, and now we carry little pieces of DNA from our ancient cousins. Our paper also highlights the deletion polymorphisms … Continue reading New paper: Different Neanderthal ancestors

New review: Archaic hominin introgression into modern human genomes

I wrote a new review paper for the Yearbook of Physical Anthropology. It summarizes some the recent insights from the genomes of archaic humans (e.g., Neanderthals, Denisovans, etc.) within an anthropological framework. Specifically, I tried to answer the following questions: How have genomic data from archaic hominins changed our view of human evolution? Is there any doubt … Continue reading New review: Archaic hominin introgression into modern human genomes

Special Issue: A new generation of anthropological genetics

I am pleased to announce that the online version of the Special Issue in Human Biology which I edited has now come out. It represents, in my opinion, the best examples of the new and exciting work in our field, anthropological genetics. The articles explore an ocean of exciting new questions about human uniqueness and … Continue reading Special Issue: A new generation of anthropological genetics

New paper: Of archaic admixture in Africa, cherries, and serendipity

We have a new paper -two years in the making - where we showed evidence for introgression from an African archaic hominin to the ancestors of modern humans. This is a relatively big and, I have to admit, a serendipitous finding, corroborating the emerging notion that an "interbreeding bonanza" has shaped our ancestors. I do … Continue reading New paper: Of archaic admixture in Africa, cherries, and serendipity

New paper: Evolutionary history of a common psoriasis associated deletion

Following up our earlier insights into "ancient" human deletion polymorphisms that are shared with Neanderthals or Denisovans, we published a paper in BMC Evolutionary Biology, describing a small, but neat example of likely balancing selection acting on a large, common and psoriasis-associated deletion in humans. The haplotype that harbors this deletion show unusually high variation and an … Continue reading New paper: Evolutionary history of a common psoriasis associated deletion

First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces

We have our first paper from the Buffalo laboratory published at Molecular Biology and Evolution (link here, it is Open Access). The paper describes polymorphic human deletions that are shared with Neandertals or Denisovans. Most of these deletions are not introgressed from ancient hominins, but rather have been lingering around since before Human/Neandertal/Denisovan ancestor. As expected majority … Continue reading First paper from our lab – Ancient deletions strike again and mysterious ways of adaptive forces