New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health

A new review paper by the mighty @marie_saitou on the difficulties and promises in integrating evolutionary framework and investigation of genomic structural variants. We talk a lot about how structural variants of different types likely affect function and have evolutionary impact on human phenotypic variation. But, we keep missing these signatures because: 1. They are … Continue reading New review: An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health

New Paper: A new method to investigate the haplotype context of duplicated genes

We have reported a computational method to detect the haplotypes harboring polymorphic gene duplications in the human genome variation dataset. This study is now published in Genome Biology and Evolution. The maestro (is it maestra?), herself drew an amazing image to accompany the piece (hopefully the next cover of the journal?).  Polymorphic duplications can be … Continue reading New Paper: A new method to investigate the haplotype context of duplicated genes

New paper: Independent amylase gene duplications

Stefan (Ruhl) and I recently published a comprehensive survey of the amylase gene copy number and salivary enzyme activity among mammalian species eLife. Petar (Pajic) was the driving force for the sample collection and analysis. Briefly, we found that 1. Amylase copy number evolves extremely fast leading to independent (I daresay convergent) bursts among mammals … Continue reading New paper: Independent amylase gene duplications

New paper: Hotspots of structural variation

Onta (Yen Lung Lin) led the charge in this careful characterization of regions in the genome where that lead to the recurrent formation of structural variation. The paper "Fine-scale characterization of genomic structural variation in the human genome reveals adaptive and biomedically relevant hotspots" is now published in GBE.  This paper has given us some … Continue reading New paper: Hotspots of structural variation

New Paper: An incomplete sweep of a metabolizing gene

A whole gene deletion sounds awful! You lose one entire gene and hence the protein that this gene is coding.  However, there exist several gene deletions which have been maintained polymorphically among human populations. In our previous work, we found that a cellular detoxification gene, the GSTM1, to remain polymorphically deleted in both humans and … Continue reading New Paper: An incomplete sweep of a metabolizing gene

New paper: Evolutionary biology of cellular aging (We got the cover)

An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence Press release by Charlotte Hsu Academic minute podcast by our collaborator Ekin Atilla The evolution of cellular senescence is a remarkable question. It connects to development, organismal life-span, protection against cancer, and its rate seems to vary between species. Moreover, since life-span of … Continue reading New paper: Evolutionary biology of cellular aging (We got the cover)

Special Issue: A new generation of anthropological genetics

I am pleased to announce that the online version of the Special Issue in Human Biology which I edited has now come out. It represents, in my opinion, the best examples of the new and exciting work in our field, anthropological genetics. The articles explore an ocean of exciting new questions about human uniqueness and … Continue reading Special Issue: A new generation of anthropological genetics