New paper: Evolutionary biology of cellular aging

An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence Press release by Charlotte Hsu The evolution of cellular senescence is a remarkable question. It connects to development, organismal life-span, protection against cancer, and its rate seems to vary between species. Moreover, since life-span of the cell is inherently linked to how much … Continue reading New paper: Evolutionary biology of cellular aging

Special Issue: A new generation of anthropological genetics

I am pleased to announce that the online version of the Special Issue in Human Biology which I edited has now come out. It represents, in my opinion, the best examples of the new and exciting work in our field, anthropological genetics. The articles explore an ocean of exciting new questions about human uniqueness and … Continue reading Special Issue: A new generation of anthropological genetics

New Paper: VCF2TREE – A phylogenetic tool

Erica (Duo Xu) has spearheaded an effort to compile all the small, different methods that we developed for analyzing population genomics data to construct locus-specific phylogenies into a streamlined pipeline. Yousef Jaber, a bright undergrad from our computer science department, end up making a nice GUI for this pipeline. We hope that it would be … Continue reading New Paper: VCF2TREE – A phylogenetic tool

New paper: Of archaic admixture in Africa, cherries, and serendipity

We have a new paper -two years in the making - where we showed evidence for introgression from an African archaic hominin to the ancestors of modern humans. This is a relatively big and, I have to admit, a serendipitous finding, corroborating the emerging notion that an "interbreeding bonanza" has shaped our ancestors. I do … Continue reading New paper: Of archaic admixture in Africa, cherries, and serendipity

New paper: Of light, duplications and UV protection

We have helped Cemali Bekpen and the Max Planck Evolutionary Biology Group of Dr. Tautz in resolving a very complicated and variable gene duplication. Even though, some of the trends remain fuzzy, it is now clear that gene duplications of SPATA31 diversified in humans and remain variable. What is more, some of their function has to do … Continue reading New paper: Of light, duplications and UV protection

New Paper: Lipids and transcripts within the context of cellular senescence

We now published a paper with Atilla Lab describing the systems level analyses of lipidome and transcriptome as the cells age (i.e., as they stop dividing). Our results highlight the multiple roles of different lipid families are playing in this cellular process. The paper got published in Molecular Biosystems - Here is the link (behind a pay-wall unfortunately). … Continue reading New Paper: Lipids and transcripts within the context of cellular senescence