The lab is now affiliated with Program in Evolution, Ecology and Behavior

We are now affliated iwth the Program in Evolution, Ecology and Behavior (EEB) in University at Buffalo. This may be a good opportunity for graduate students and visiting scientists interested in evolutionary/anthropological genomics to interact with our group. So, we are looking forward to working with the EEB folk in the coming years. Also, Omer will… Continue reading The lab is now affiliated with Program in Evolution, Ecology and Behavior

New Paper in Genome Research: Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division

We have a new paper regarding variation of retrotransposed genes among healthy individuals: In primates and other animals reverse transcription of mRNA followed by genomic integration creates retroduplications. Expressed retroduplications are either 'retrogenes' coding for functioning proteins or expressed 'processed pseudogenes', which can function as noncoding RNAs. To date, little is known about the variation… Continue reading New Paper in Genome Research: Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division

New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

Our efforts to resequence and analyze primate genomes with a focus on genomic structural variation has now been published. Here is the link for the paper and here is the link for the curated datasets. The study, I think, is a major step forward to understand evolution of primate genomes. Now that several papers from Eichler… Continue reading New Paper in PNAS: Primate genome architecture influences structural variation mechanisms and functional consequences

New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G

This paper describing a nice evolutionary story about interaction between HIV and the host immune system, is mostly the effort of our collaborators in Mount Sinai. You can find the abstract below and here is the link to the article.  APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 and other lentiviruses. Most of these… Continue reading New Paper in Journal of Virology: Vif proteins from diverse primate lentiviral lineages use a same binding site in APOBEC3G

New paper in PLoS Genetics – Balancing Selection shaping the distribution of a common deletion variant

Finally, our manuscript entitled "Balancing selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence" was published in PLoS Genetics. You can find it here... It is Open Access. Also, link to the post regarding the manuscript in Dienekes' Anthropology Blog. Note the several interesting points that commentators were raising. Another recent blog post… Continue reading New paper in PLoS Genetics – Balancing Selection shaping the distribution of a common deletion variant

Bilim kazanında günün kepçesi oldum

Bilim kazanı için İlker ve Aysu ile uzunca bir muhabbet ettik. Tatlı dillerinden ayrılıp da eve dönmem gece yarısı 1'i buldu. Ama galiba ayırdığımız 5 saate değdi. İnsanı insan yapan nedir diye sorduk - Dinlemek için basın buraya. Bu arada iyice yaşlandığımı tasdikleyecek ama, FatBoy Slim'in şu klibini hatırlamadım değil... 🙂 https://www.youtube.com/watch?v=ub747pprmJ8  

Genomeweb article on our work

Some of our work has been highlighted in a feature article in GenomeWeb: From the article entitled "Copy Machines": --- CNVs also have potentially significant implications for understanding evolutionary processes, Lee notes, citing a recent paper that he and his fellow Harvard researchers Rebecca Iskow and Omer Gokcumen published in Trends in Genetics in which they suggest that, although… Continue reading Genomeweb article on our work

Paper in PNAS – Regulatory element copy number differences shape primate expression profiles

I am the co-first author of a recent paper with Rebecca (Iskow), discussing the impact of copy number differences between primate species to expression regulation. I do think that copy number differences of regulatory genes (e.g., transcription factors) and other regulatory regions (non-coding RNAs, enhancer, etc.) may be key to understand phenotypic variation among primates.… Continue reading Paper in PNAS – Regulatory element copy number differences shape primate expression profiles

Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation

We have a new review paper in Trends in Genetics regarding the role of Copy Number Variants (CNVs) in human adaptation. I think, it lays out some of the emerging promises (and hardships) of the field and throws in one or two very cool ideas on the evolutionary mechanisms through which CNVs can affect phenotypic variation in… Continue reading Paper in Trends in Genetics – Exploring the role of copy number variants in human adaptation